Fig. 4: Exhausted T-cells from rs781745126-T carriers express less LAG-3. | Nature Communications

Fig. 4: Exhausted T-cells from rs781745126-T carriers express less LAG-3.

From: Start codon variant in LAG3 is associated with decreased LAG-3 expression and increased risk of autoimmune thyroid disease

Fig. 4

PBMCs from 28 heterozygous rs781745126-T carriers (CT) and 28 non-carrier controls (CC) matched for age and sex were stimulated for 48 h with Staphylococcal Enterotoxin B (SEB) to upregulate LAG-3 and PD-1 expression and induce exhaustion. a LAG-3+PD-1+ cells (red square) representing exhausted T-cells. b Surface expression intensity (geometric mean) of LAG-3 on double-positive LAG-3+PD-1+ exhausted CD4+ and CD8+ T-cells. Paired t-test with two-sided P-values was used to compare carriers (blue) and non-carriers (red).

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