Fig. 2: Induction of fold changes by malonate and sulfate ions.
From: An ancestral fold reveals the evolutionary link between RNA polymerase and ribosomal proteins
A Two malonates in the crystal structure of chemically synthesized design-1 in the DPBB form. B Two sulfates in the crystal structure of chemically synthesized design-1 in the DZBB form. The five residues related to the coordination of ions are shown as stick models. C, D The ANS fluorescence spectra of design-1 in the presence of increasing concentrations of (C) malonate or (D) ammonium sulfate. Similar experiments were performed twice, and representative data are shown. Source data are provided as a Source Data file. E The scheme of the dual-folding mechanism of design-1 dependent on the types of ions.
