Fig. 5: The proposed evolutionary network between the modern four β-barrels through the missing link fold, DZBB. | Nature Communications

Fig. 5: The proposed evolutionary network between the modern four β-barrels through the missing link fold, DZBB.

From: An ancestral fold reveals the evolutionary link between RNA polymerase and ribosomal proteins

Fig. 5

The experimentally verified routes between each mutant pair are connected with black arrows, and the minimal necessary mutations between designs are written in purple. The DPBB protein’s evolutionary pathway, which was examined in the previous study, is highlighted in a light red background. The evolutionary routes of DZBB, RIFT, OB, and SH3 are highlighted in gray, light blue, pink, and green backgrounds, respectively. Representative proteins conserving each barrel fold are shown in the upper panel.

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