Fig. 8: Schematic illustration of our study.
From: Erythroid-intrinsic activation of TLR8 impairs erythropoiesis in inherited anemia
TLR8 in immune cells activates NF-κB signaling upon ligand ligation which is crucial for inflammatory cytokine production. Nonetheless, activation of TLR8 interferes with ANXA2-mediated plasma membrane localization of STAT5 and subsequent activation, ultimately leading to impaired erythropoiesis due to disrupted EPO signaling in erythroid cells.
