Fig. 4: Neural results: a priori higher-level pain processing neuromarker. | Nature Communications

Fig. 4: Neural results: a priori higher-level pain processing neuromarker.

From: Placebo treatment affects brain systems related to affective and cognitive processes, but not nociceptive pain

Fig. 4

A The SIIPS signature, fMRI measure optimized to predict pain beyond nociception84. Dominant model parameters are highlighted by transparency scaling. B The mean SIIPS scores (based on dot product) across participants are presented, in the Control (red) and Placebo (blue) condition, for each combination of modality and stimulus level. Error bars represent within-participant standard error of the mean, based on Morey, 2008107. For additional visualizations see Supplementary Fig. 4. N = 392 participants. Asterisks represent significance of the placebo effect (mixed-effects model, uncorrected): *p < 0.05, **p < 0.01, ***p < 0.001. For visualizations of SIIPS subregions see Supplementary Figs. 5 and 6.

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