Table 2 Statistics for a priori nociceptive ROIs: placebo effect

From: Placebo treatment affects brain systems related to affective and cognitive processes, but not nociceptive pain

Region

Modality

Estimate

95% CI

SE

t

DF

p value

aMCC

Thermal

0.003

[āˆ’0.068, 0.075]

0.036

0.10

223.5

0.924

Mechanical

0.095

[0.021, 0.169]

0.038

2.53

398.2

0.012

dpIns L

Thermal

0.018

[āˆ’0.050, 0.086]

0.035

0.52

246.1

0.602

Mechanical

0.143

[0.075, 0.212]

0.035

4.11

498.8

<0.001

dpIns R

Thermal

0.027

[āˆ’0.042, 0.096]

0.035

0.77

226.7

0.444

Mechanical

0.136

[0.065, 0.207]

0.036

3.78

381.2

<0.001

PAG

Thermal

0.01

[āˆ’0.073, 0.094]

0.042

0.24

213.9

0.809

Mechanical

āˆ’0.001

[āˆ’0.083, 0.082]

0.042

āˆ’0.02

231.5

0.988

Med Thal

Thermal

0.016

[āˆ’0.060, 0.091]

0.038

0.41

364.1

0.685

Mechanical

0.142

[0.069, 0.215]

0.037

3.81

472.3

<0.001

VPL/M Thal L

Thermal

0.061

[āˆ’0.015, 0.136]

0.038

1.59

223.9

0.114

Mechanical

0.153

[0.082, 0.225]

0.036

4.20

329.3

<0.001

VPL/M Thal R

Thermal

0.047

[āˆ’0.024, 0.119]

0.036

1.31

199.5

0.193

Mechanical

0.108

[0.036, 0.180]

0.037

2.93

389.4

0.004

  1. Full statistics for the mixed effects models of the activity in each a priori ROI, for the placebo effect. Significant p values (uncorrected pā€‰<ā€‰0.05) are marked in bold. Negative t-values indicate reductions with Placebo vs. Control, which was the expected direction; positive t-values indicate paradoxical increases.
  2. CI confidence interval, DF degrees of freedom, L left, R right, aMCC anterior midcingulate cortex, dpIns dorsal posterior insula, Med Thal medial thalamus, VPL/M Thal ventral posterior thalamus, PAG periaqueductal gray.
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