Table 4 Statistics for a priori ROIs for higher-level pain processing: placebo effect

From: Placebo treatment affects brain systems related to affective and cognitive processes, but not nociceptive pain

Region

Modality

Estimate

95% CI

SE

t

DF

p value

dlPFC L 1

Thermal

0.105

[0.035, 0.176]

0.036

2.95

408.8

0.003

Mechanical

0.114

[0.040, 0.187]

0.037

3.05

395.0

0.002

dlPFC L 2

Thermal

0.032

[āˆ’0.044, 0.108]

0.039

0.82

229.2

0.413

Mechanical

0.068

[āˆ’0.008, 0.144]

0.038

1.77

321.5

0.077

dlPFC R

Thermal

0.083

[0.014, 0.151]

0.035

2.37

473.7

0.018

Mechanical

0.049

[āˆ’0.027, 0.125]

0.039

1.27

260.8

0.207

Lateral OFC

Thermal

0.076

[0.010, 0.142]

0.034

2.26

362.3

0.024

Mechanical

0.014

[āˆ’0.060, 0.088]

0.038

0.36

500.5

0.717

Anterior OFC 1

Thermal

0.072

[āˆ’0.001, 0.145]

0.037

1.94

246.5

0.054

Mechanical

0.024

[āˆ’0.051, 0.098]

0.038

0.62

405.5

0.534

Anterior OFC 2

Thermal

0.081

[0.007, 0.155]

0.038

2.14

373.3

0.033

Mechanical

0.106

[0.026, 0.187]

0.041

2.60

224.2

0.010

Mid-lateral OFC L

Thermal

0.062

[āˆ’0.015, 0.140]

0.039

1.58

321.3

0.115

Mechanical

0.044

[āˆ’0.029, 0.118]

0.037

1.18

748.7

0.238

Mid-lateral OFC R

Thermal

0.069

[āˆ’0.007, 0.145]

0.039

1.79

360.6

0.075

Mechanical

0.048

[āˆ’0.026, 0.121]

0.037

1.28

765.3

0.201

NAc L

Thermal

0.001

[āˆ’0.078, 0.079]

0.040

0.02

280.3

0.987

Mechanical

0.156

[0.080, 0.233]

0.039

4.02

434.3

<0.001

NAc R

Thermal

0.014

[āˆ’0.061, 0.090]

0.038

0.37

376.5

0.712

Mechanical

0.178

[0.105, 0.251]

0.037

4.78

370.2

<0.001

  1. Full statistics for the mixed effects models of the activity in each a priori higher-level pain processing ROI, for the placebo effect. Significant p values (uncorrected p < 0.05) are marked in bold. Significant p values (uncorrected p < 0.05) are marked in bold.
  2. CI confidence interval, DF degrees of freedom, L left, R right, dlPFC dorsolateral prefrontal cortex, OFC orbitofrontal cortex, NAc nucleus accumbens.