Table 2 Predictive value of plasma metabolites

From: Plasma metabolomics reveals the shared and distinct metabolic disturbances associated with cardiovascular events in coronary artery disease

Model

The composite of CV events

CV death

Heart failure

MI/Stroke

AUC

p

AUC

p

AUC

p

AUC

p

The key metabolites combination

0.64 (0.58, 0.70) b

–

0.71 (0.64, 0.79) c

–

0.89 (0.84, 0.94) d

–

0.63 (0.55, 0.70) e

–

TIMI variables a

0.63 (0.57, 0.69)

0.010

0.68 (0.60, 0.74)

0.008

0.68 (0.59, 0.77)

1.483 × 10−6

0.63 (0.56, 0.70)

0.061

TIMI variables and Metabolites

0.70 (0.64, 0.75)

 

0.76 (0.70, 0.83)

 

0.91 (0.86, 0.94)

 

0.69 (0.62, 0.76)

 

hs-cTnT

0.67 (0.61, 0.72)

0.543

0.73 (0.66, 0.80)

0.879

0.82 (0.74, 0.88)

0.029

0.63 (0.56, 0.70)

0.924

hs-cTnT and Metabolites

0.65 (0.59, 0.70)

 

0.73 (0.66, 0.80)

 

0.89 (0.84, 0.94)

 

0.63 (0.55, 0.70)

 

NT-proBNP

0.70 (0.64, 0.76)

0.697

0.80 (0.74, 0.86)

0.497

0.88 (0.83, 0.93)

0.003

0.61 (0.54, 0.69)

0.232

NT-proBNP and Metabolites

0.71 (0.65, 0.76)

 

0.81 (0.75, 0.87)

 

0.94 (0.91, 0.97)

 

0.65 (0.58, 0.72)

 
  1. The DeLong’s test for two correlated ROC curves were two-sided test. Considering that only three tests were performed for each outcome, no multiple comparison correction was made for each test.
  2. CV cardiovascular, MI myocardial infarction.
  3. aTIMI variables included age, current smoking, hypertension, diabetes mellitus, previous stroke, previous HF, previous PAD, previous PCI/CABG, and eGFR.
  4. bThe key metabolites combination of the composite of cardiovascular events were identified by Lasso algorithm, including cystine, hexenoylcarnitine (Car(6:1)), Oxooctadecadienoylcarnitine (Car(18:3-O)), Hexadecatrienoylcarnitine (Car(16:3)), 5-Acetylamino−6-amino-3-methyluracil (AAMU), erucic acid, suberic acid, Vanillylmandelic acid, Mandelic acid, 3-(2,3,4-Trimethoxyphenyl)propanoic acid, N4-Acetylcytidine, N-[3-(2-oxopyrrolidin-1-yl)propyl]acetamide, 3-Hydroxyoctanoic acid, Phthalide.
  5. cThe key metabolites combination of cardiovascular death were identified by Lasso algorithm, including Tetradecadienoylcarnitine (Car(14:2)), Car(18:3-O), Hexadecanedioic acid, Vanillylmandelic acid, N-[3-(2-oxopyrrolidin-1-yl)propyl]acetamide, 3-Hydroxyoctanoic acid, Phthalide, N,N-Dimethylarginine (ADMA), Homoarginine.
  6. dThe key metabolites combination of heart failure were identified by Lasso algorithm, including Cystine, N-Acetyl-arginine, Homoarginine, Erucic acid, N4-Acetylcytidine, 11beta-hydroxyandrost-4-ene-3,17-dione, Cortisol, LPA(20:5), LPC(20:4), LPC(O-16:0), PC(10:0/10:0), PC(22:2), PC(8:0/8:0).
  7. eThe key metabolites combination of myocardial infarction/stroke were identified by Lasso algorithm, including 1,7-Dimethylxanthine, 3-(2,3,4-Trimethoxyphenyl) propanoic acid, Erucic acid, Car(16:3), Mandelic acid, N4-Acetylcytidine, Oxooctanoylcarnitine (Car(8:1-O)), Palmitoleylcarnitine (Car(16:1)), Suberic acid, Theobromine, Theophylline, Vanillylmandelic acid.
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