Fig. 5: BMP4 activates PrE regulons.
From: Cell fate decision by a morphogen-transcription factor-chromatin modifier axis
a Plot shows the top 5 regulons of PrE in JGES under BMP4+ condition. b Network plots show the transcription factors and their target genes. c and d UMAP show the regulon scores calculated by SCENIC (c) and the expression level (d) of transcription factors. e Histogram shows Oct4 GFP positive iPS colonies numbers in different groups, data are mean ± s.d., two-sided, unpaired t-test; n = 3 independent experiments, *p < 0.05, **p < 0.01, ***p < 0.001. f Histograms show the qPCR results of PrE genes relative expression level of every group, n = 3 independent experiments, error bars here represent mean with SD.
