Fig. 5: Cumulative incidence of secondary outcomes stratified by transthyretin levels.

This figure depicts the cumulative incidence curves for atherosclerotic cardiovascular disease (composite of stroke and coronary heart disease) (A), cardiovascular disease (composite of heart failure, stroke, and coronary heart disease) (B), all-cause mortality (C), and cardiovascular mortality (D) stratified by TTR levels. The cumulative incidence curves were generated using the Kaplan-Meier method. Based on TTR levels, sex-specific high (≥median) and low (<median) TTR groups were created. Low and high TTR groups are depicted in red and blue, respectively. The p-value comparing the TTR groups was derived using the log rank test.