Table 1 Baseline characteristics stratified by V142I TTR variant carrier status

From: Determinants of transthyretin levels and their association with adverse clinical outcomes among UK Biobank participants

 

Overall (n = 35,206)

V142I carrier (n = 39)

V142I non-carrier (n = 35,167)

Age, y

58.0 (50.0, 63.0)

51.0 (45.0, 58.0)

58.0 (45.0, 58.0)

Females

19,399 (55.1)

23 (59.0)

19,376 (55.1)

Systolic blood pressure, mmHg

137.7 (18.5)

137.2 (19.0)

137.7 (18.5)

Diastolic blood pressure, mmHg

82.2 (10.2)

84.7 (10.5)

82.2 (10.2)

Body mass index, kg/m2

27.3 (4.7)

30.0 (5.9)

27.3 (4.7)

Townsend deprivation Indexa

−2.1 (−3.6, 0.7)

3.3 (−0.2, 6.8)

−2.1 (−3.6, 0.7)

Transthyretin levels, NPXb

−0.1 (0.3)

−0.5 (0.3)

−0.1 (0.3)

  1. aTownsend deprivation index is a measure of socioeconomic deprivation that takes car ownership, house ownership, household overcrowding, and employment into consideration. A higher value indicates higher socioeconomic deprivation.
  2. bNPX normalized protein expression. NPX refers to the unit of quantification for analytes measured on the Olink platform. The NPX values are measured on the log2 scale, with lower values indicating lower levels of the analyte.
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