Table 3 Association of study outcomes with transthyretin levels

From: Determinants of transthyretin levels and their association with adverse clinical outcomes among UK Biobank participants

 

Low transthyretin levels (n = 15,716)

High transthyretin levels (n = 15,713)

p-value

Heart failure

  Events

494 (3.1)

401 (2.6)

 

  Incidence rate

2.39 (95% CI: 2.19–2.62)

1.92 (95% CI: 1.74–2.12)

0.001

All-Cause mortality

  Events

1774 (11.3)

1347 (8.6)

 

  Incidence rate

8.53 (95% CI: 8.14–8.93)

6.40 (95% CI: 6.07–6.75)

<0.001

Cardiovascular mortality

  Events

250 (1.6)

159 (1.0)

 

  Incidence rate

1.20 (95% CI: 1.05–1.37)

0.76 (95% CI: 0.64–0.89)

<0.001

Atherosclerotic cardiovascular disease

  Events

1291 (8.2)

1187 (7.6)

 

  Incidence rate

6.42 (95% CI: 6.08–6.78)

5.82 (95% CI: 5.50–6.16)

0.01

Cardiovascular disease

  Events

1622 (10.3)

1458 (9.3)

 

  Incidence rate

8.12 (95% CI: 7.73–8.53)

7.19 (95% CI: 6.83–7.57)

<0.001

  1. The p-value for the difference in two incidence rates was obtained using the Chi-squared statistic.
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