Fig. 6: Genetic differences of metastases and primary melanoma indicate early dissemination of metastatic clones. | Nature Communications

Fig. 6: Genetic differences of metastases and primary melanoma indicate early dissemination of metastatic clones.

From: The genetic evolution of acral melanoma

Fig. 6

a Evolutionary trees for three cases, one with a cutaneous metastasis and two with lymph node metastases showing comparatively early branching of the metastatic lineages from the corresponding primary melanomas. In two other melanomas multiple metastases were analyzed (b, c). The lineages of the brain metastases diverge early from the primary in both patients. The in situ portion of case 102 was computationally inferred to contain two different subclones. b, c Created with BioRender.com released under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International license (https://creativecommons.org/licenses/by-nc-nd/4.0/deed.en).

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