Fig. 2: Scope of the hydroamination - building blocks and pharmaceutical core structures. | Nature Communications

Fig. 2: Scope of the hydroamination - building blocks and pharmaceutical core structures.

From: Regioselective hydroamination of unactivated olefins with diazirines as a diversifiable nitrogen source

Fig. 2

A Monosubstituted alkene examples. B Disubstituted alkene examples. C Trisubstituted alkene examples. D Cyclic alkene examples. Reactions conducted with alkene (0.1 mmol), 1 (0.15 mmol, 1.5 eq), cat-1 (0.005 mmol, 0.05 eq), t-BuOOt-Bu (0.1 mmol, 1 eq), PhSiH3 (0.1 mmol, 1 eq), DCE (400 µL) and IPA (100 µL) at 40 °C for 20 h under argon atmosphere with protection from light. Isolated yields are reported. aReaction run at 0.1 mmol scale with perfluorinated diazirine 1. bReaction run at 1 g scale. cReaction run with IPA (100 µL) as the only solvent for 30 h. dReaction conducted with alkene (0.1 mmol), 1 (0.15 mmol, 1.5 eq), Mn(dpm)3 (0.005 mmol, 0.05 eq), PhSiH3 (0.1 mmol, 1 eq), DCE (400 µL) and IPA (100 µL) at 0 °C for 2 h under argon atmosphere with protection from light. Mn(dpm)3 = Tris(2,2,6,6-tetramethyl-3,5-heptanedionato)manganese(III). DCE = dichloroethane, IPA = isopropyl alcohol.

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