Fig. 7: Distribution of lamin-associated and H4K20Me3-modified genomic domains in Setd8-LKO hepatocytes.
From: Endonucleosis mediates internalization of cytoplasm into the nucleus
a Genome Browser tracks showing normalized CUT&Tag reads of Lamin A/C-associated and H4K20Me3-occupied genomic regions on the entire chromosome 6 (left panel) and a 30 Mb region of chromosome 6 (panel at right). b Venn diagram showing the extent of overlap between Lamin A/C and H4K20Me3 CUT&Tag peaks in wild type liver nuclei. c, d Venn diagram comparing Lamin A/C (c) and H4K20Me3 (d) CUT&Tag peaks between wild type and Setd8-LKO mice 24 h after TCPOBOP treatment. “Loss” indicates peaks present only in wild type livers, “Gain” indicates new peaks in Setd8-LKO livers, while “Constant” correspond to peaks found in both, the wild type and the Setd8-LKO livers.
