Fig. 1: Outline of the MethNet pipeline.
From: MethNet: a robust approach to identify regulatory hubs and their distal targets from cancer data
Paired RNA-seq and DNA-methylation data were accessed from TCGA. The expression of every protein coding gene across every cancer dataset was modeled as a function of the methylation status in a 1 Mb radius surrounding the gene to generate a set of regulatory networks across all cancers. These were aggregated to produce a network of robust associations that were used to identify regulatory elements and hubs.
