Fig. 2: Manhattan plots showing associations between genetically predicted DNA methylation at CpGs and cancer risk.
From: Integrating muti-omics data to identify tissue-specific DNA methylation biomarkers for cancer risk
Association analyses were conducted using SPrediXcan and all statistical tests were two-sided. The x-axis denotes chromosomes and the y-axis is \({-\log }_{10}P\). The dashed red line in each plot represents the Bonferroni-corrected threshold, which was 4.93 × 10−7 for breast cancer, 2.53 × 10−7 for colorectal cancer, 3.98 × 10−7 for renal cell cancer, 2.55 × 10−7 for lung cancer, 2.66 × 10−7 for ovarian cancer, 3.28 × 10 −7 for prostate cancer, and 4.22 × 10−7 for testicular germ cell cancer. Loci (cytobands) instead of CpGs are displayed because of the huge number of cancer-associated CpGs. All loci containing CpG-cancer associations that might be independent of GWAS-identified signals are annotated. Potential novel loci are highlighted in red. Source data are provided as a Source Data file.
