Fig. 6: Common host metabolic pathways and genes essential for Plasmodium and Theileria schizont survival in nucleated host cells. | Nature Communications

Fig. 6: Common host metabolic pathways and genes essential for Plasmodium and Theileria schizont survival in nucleated host cells.

From: Host cell CRISPR genomics and modelling reveal shared metabolic vulnerabilities in the intracellular development of Plasmodium falciparum and related hemoparasites

Fig. 6

Metabolic pathway association of 28 genes identified as the overlap of 99 metabolic host genes from Theileria essentialome and 234 host genes predicted to be essential for liver-stage P. falciparum in at least one of the parasitosomes, i.e., at least one simulated metabolic configuration of P. falciparum in the liver-stage. Seven genes essential for Theileria and P. falciparum in all metabolic configurations were characterized as the overlap of the 99 metabolically essential Theileria genes and the 19 host genes to be predicted as essential for all parasitosomes. Genes further validated experimentally in T. annulata (*) and P. berghei (#).

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