Fig. 4: Factor analysis within interneuron subclasses.

A (left) UMAP of the PTHLH subclass from the CN, colored by the value of the factor obtained by running factor analysis. (middle) Factor weights associated with each gene. (right) UMAP of the PTHLH subclass interneurons colored by the expression level of (top row) the genes with the top three and (bottom row) bottom three weights on the factor. B–D (left) Factor values, (middle) weights distributions and (right) expression of genes with largest contributions to the factor obtained for the PTHLH subclass from the Pu, the TAC3 subclass from the CN, and the TAC3 subclass from the Pu, respectively. CN caudate nucleus, Pu putamen.