Fig. 2: Dwell-time densities are peaked — the observed process, therefore, is non-Markovian.
From: Single gene analysis in yeast suggests nonequilibrium regulatory dynamics for transcription
Survival curves of internal ON periods for a wild type, b chd1\(\Delta\), c isw2\(\Delta\), and d pho4. Measurements are indicated by blue dots and biexponential fits by blue curves. Inserts show the corresponding density function; \(\mu\) is the mean period length (the average of 300 bootstrap replicates \(\pm\) bootstrap standard deviation). The median of the distribution is highlighted by stippled red lines. Arrows point at the intercept of the density function with the ordinate for chd1\(\Delta\) and isw2\(\Delta\). The average density at \(t=0.01\) across 300 bootstrap replicates (cf. “Methods”) was \(-0.001\pm 0.003\) (wild type), \(+0.002\pm 0.0024\) (chd1\(\Delta\)), \(+0.0024\pm 0.0025\) (isw2\(\Delta\)), and \(+0.01\pm 0.004\) (pho4), \(\pm\) the standard deviation across bootstrap replicas. Period lengths were obtained by CPD analysis (see “Methods”) from 218 (wild type), 205 (chd1\(\Delta\)), 291 (isw2\(\Delta\)), and 158 (pho4\(\Delta\)[75–90]) sample paths (cells), observed over a time period of 1250 s.
