Fig. 3: β-diversity PCA plots of overall nasopharyngeal resistome composition stratified per time point. | Nature Communications

Fig. 3: β-diversity PCA plots of overall nasopharyngeal resistome composition stratified per time point.

From: Prolonged hospitalization signature and early antibiotic effects on the nasopharyngeal resistome in preterm infants

Fig. 3

Principal component analysis (PCA) based on Euclidean distances of CLR-transformed ARG abundances (i.e., Aitchison dissimilarity) between samples, visualizing the overall nasopharyngeal resistome composition stratified for antibiotic-treated infants and naive at time point A T1 (baseline) and B T2 (immediately after cessation of early antibiotic therapy). Each data point represents the resistome composition of one sample. The ellipses represent the 95% confidence interval around the centroid of resistome composition for each group. Statistical significance (adjusted P-values, calculated using the Benjamini–Hochberg method) and effect size (R2) of the differences in beta diversity were assessed using PERMANOVA test. In panel (C), the results of the PERMANOVA-tests for the later time points are presented. Data points of early antibiotic-treated infants are colored red and those of naive infants are blue. PERMANOVA permutational multivariate analysis of variance; p.adj = adjusted P-values. Source data are provided as a Source data file.

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