Fig. 5: Schematic representation of copper signaling and CTR1 repression. | Nature Communications

Fig. 5: Schematic representation of copper signaling and CTR1 repression.

From: PTPN2 copper-sensing relays copper level fluctuations into EGFR/CREB activation and associated CTR1 transcriptional repression

Fig. 5

(top) Proposed mechanism of copper-stimulated EGFR activation, with downstream CREB TF activity and transcriptional repression of CTR1. (bottom) Decreased Cu levels result in downregulation of the pathway shown on the top. Figure 5 created with BioRender.com released under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International license.

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