Table 3 Minimum inhibitory concentration (MIC) values of library DMxiPeny(x:y) against clinically isolated drug-resistant bacterial

From: AI-guided few-shot inverse design of HDP-mimicking polymers against drug-resistant bacteria

Strain

MIC(μg mL−1)

 

10:0

9:1

8:2

7:3

6:4

5:5

Staphylococcus aureus USA300

25

12.5

12.5

12.5

12.5

12.5

Staphylococcus aureus MU50

25

12.5

12.5

12.5

12.5

25

Staphylococcus aureus Newman

50

25

12.5

12.5

12.5

50

Staphylococcus aureus R02

25

12.5

12.5

12.5

12.5

25

Staphylococcus aureus R03

25

25

12.5

12.5

12.5

25

Vancomycin resistant enterococcus-1

12.5

6.25

6.25

6.25

6.25

12.5

Vancomycin resistant enterococcus-2

12.5

6.25

6.25

6.25

6.25

12.5

Escherichia coli JM109

25

12.5

12.5

12.5

12.5

25

Escherichia coli R19

50

25

12.5

12.5

12.5

25

Pseudomonas aeruginosa R09

12.5

6.25

6.25

6.25

6.25

25

Pseudomonas aeruginosa R10

12.5

12.5

6.25

6.25

6.25

25

  1. Values in bold indicate the performance of DM0.8iPen0.2 which is chosen as the optimal antibacterial candidate.