Fig. 9: N-glycan analysis reveals significant differences across N-glycan profiles of proteomic MB subtypes. | Nature Communications

Fig. 9: N-glycan analysis reveals significant differences across N-glycan profiles of proteomic MB subtypes.

From: Multiomic profiling of medulloblastoma reveals subtype-specific targetable alterations at the proteome and N-glycan level

Fig. 9

A STRING network analyses of differentially abundant proteins involved in N-linked glycosylation. B Scheme of N-glycan analyses. C Schematic visualization of N-glycan types. D Venn diagrams showing overlap of identified glycans per MB proteome subtype (npWNT = 3, npSHHt = 3, npSHHs = 3, npG3 = 3, npG3myc = 3, npG4 = 3). E PCA, based on N-glycan abundances, illustrating the separation of proteome MB subtypes at the N-glycan level. F 2D Structure visualization for pG3myc-specific N-glycans. GlcNAc N-Acetylglucosamine, Gal Galactose, Fuc Fucose, ManNAc N-Acetylmannosamine; Neu5AC N-Acetylneuraminic acid. G Venn Diagram, comparing the identified hybrid-type and complex N-glycans between proteome subtypes. n represents biologically independent human samples.

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