Fig. 6: Photothermal inhibition of the sympathetic nervous system by PtNP-shell. | Nature Communications

Fig. 6: Photothermal inhibition of the sympathetic nervous system by PtNP-shell.

From: Pt nanoshells with a high NIR-II photothermal conversion efficiency mediates multimodal neuromodulation against ventricular arrhythmias

Fig. 6

a Location of the canine LSG. b Schematic illustration of the process of photothermal modulation of LSG. c Temperature curves of LSG under NIR-II laser irradiation. d Typical thermal imaging diagram of photothermally modulated activation of LSG. e Representative images of BP elevation induced after stimulation of LSG with different voltages. Maximal SBP changes of beagle treatment with PtNP-shell or control f before and g after NIR-II exposure, n = 6 biologically independent replicates. h Quantification of the LSG neural activity recordings, n = 6 biologically independent replicates. i Representative immunofluorescent images of TH, c-Fos, and TREK1 in the LSG of beagles following different treatments. Data are shown as the mean ± S.E.M. Unpaired two-tailed Student’s t-test was applied for statistical analysis of (g). Two-way ANOVA with Tukey’s HSD test was applied for statistical analysis of (h). LSG left stellate ganglion, BP blood pressure, SBP systolic BP. Source data are provided as a Source Data file.

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