Fig. 7: PtNP-shell photothermal inhibition of the sympathetic nervous system improves MI-associated VAs. | Nature Communications

Fig. 7: PtNP-shell photothermal inhibition of the sympathetic nervous system improves MI-associated VAs.

From: Pt nanoshells with a high NIR-II photothermal conversion efficiency mediates multimodal neuromodulation against ventricular arrhythmias

Fig. 7

Modulation of LSG to protect against MI and associated VAs a schematic diagram and b flowchart. c Quantitative analysis of the ratio of sVT and VF incidence between different groups, n = 6 biologically independent replicates. d Quantitative analysis of the number of VPBs of beagles. e Typical images of VA induced by programmed electrical stimulation. f Quantitative analysis of VAs score in different groups. Effects on ventricular ERP at different sites in Beagles treatment with PtNP-shell or control g before and h after MI modeling. i Quantitative analysis of VF threshold in different groups, n = 6 biologically independent replicates. Data are shown as the mean ± S.E.M. Unpaired two-tailed Student’s t-test was applied for statistical analysis of (d, f–i). LSG left stellate ganglion, SBP systolic blood pressure, MI myocardial infarction, VPB ventricular premature beat, VT ventricular tachycardia, VF ventricular fibrillation, VA ventricular arrhythmia, ERP effective refractory period, LVA left ventricular apex, LVM median left ventricular area, LVB left ventricular base. Source data are provided as a Source Data file.

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