Fig. 1: Overall structure of ScPif1 complexed with G-quadruplex DNA.
From: Eukaryotic Pif1 helicase unwinds G-quadruplex and dsDNA using a conserved wedge
a Schematic of the truncated ScPif1 used in this study. b Cartoon representation of the crystal structure of ScPif1-G4 with the conserved domains and motifs color-coded as in (a) (1A in light blue, 2A in wheat, 2B in light pink, 2C in gray, wedge in limon, and Pif1 signature motif (PSM) in magenta). The AT11 G4 DNA is colored in orange and the ADP·AlF4− and K+ ions are shown as blue sticks and cyan spheres, respectively. The key residue R324 involved in the interaction is shown as sticks.
