Fig. 3: Structural comparison with ToPif1-G4 and DHX36-G4.
From: Eukaryotic Pif1 helicase unwinds G-quadruplex and dsDNA using a conserved wedge
a Structural superposition of ScPif1-G4 with ToPif1-G4 highlighting the conformational difference of bound G4 DNAs. The cartoon representations show ScPif1 (yellow) and ToPif1 (gray) (PDB code: 7OAR), with their wedge regions colored in lemon and red, respectively. The 2B domain of ToPif1 is colored in light pink while AT11 and c-Myc are colored in orange and cyan, respectively. b Cartoon representation of the DHX36-G4 structure (PDB code: 5VHE) with the DSM colored in blue, RecA1 in dark green, RecA2 in green, WH in violet, RL in lemon, OB domain in pink, CTE in limegreen and c-Myc G4 DNA in dark gray.
