Fig. 3: Scope of the electrocatalysed chlorination reaction.
From: Electrocatalytic continuous flow chlorinations with iodine(I/III) mediators
Reaction conditions: alkene (0.5 mmol), TMSCl (2.0 mmol), 4-iodotoluene (25 mol %), NMe4PF6 (5 mol%) in HFIP/MeCN (2:1 v/v, 0.1 M), graphite electrodes, electrode distance 0.5 mm, 2 mA/cm2 (3 F), 12 min residence time at room temperature, 600 µL reactor volume, flow rate 0.05 mL/min, isolated yields. a HFIP/MeCN/CH2Cl2 (4.2:3.1:2 v/v, 0.1 M). b HFIP/MeCN/CH2Cl2 (5.2:3.1:1 v/v, 0.1 M). c Yields were determined by 1H NMR analysis of the crude reaction mixture.
