Fig. 7: Model for translational control by Pdcd4. | Nature Communications

Fig. 7: Model for translational control by Pdcd4.

From: Human tumor suppressor protein Pdcd4 binds at the mRNA entry channel in the 40S small ribosomal subunit

Fig. 7

Pdcd4 binds at the mRNA entry site in the 40 S, where it inserts the N-terminal domain into the mRNA channel. Given the high similarity between Pdcd4 and SERBP1, it is likely that Pdcd4 may inhibit translation by blocking the mRNA channel and protecting the ribosome under nutrient deprivation. Additionally, Pdcd4 can inhibit translation by blocking the helicase activity of eIF4A at the leading edge of the ribosome, thereby inhibiting recruitment and scanning, especially during the translation of mRNAs with structured 5′ UTR.

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