Fig. 4: Scope of substrates. | Nature Communications

Fig. 4: Scope of substrates.

From: Chemo-, regio- and enantioselective hydroformylation of trisubstituted cyclopropenes: access to chiral quaternary cyclopropanes

Fig. 4

All reactions were performed on 0.2 mmol in 1 mL toluene with 1 mol % Rh(acac)(CO)2 and 2 mol % ligand under 5/5 bar (CO/H2) at 60 °C for 24 h. Rr was Determined by 1H NMR spectroscopy. Isolated yield. Ee was determined by HPLC analysis using a chiral stationary phase after a Wittig reaction with methyl (triphenylphosphoranylidene)acetate. The yields of 2t’-2x’ belong to the products after the Wittig reaction.

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