Fig. 2: Intervention effect on postprandial blood, SAT and muscle gene expression levels in men and women. | Nature Communications

Fig. 2: Intervention effect on postprandial blood, SAT and muscle gene expression levels in men and women.

From: Secondary integrated analysis of multi-tissue transcriptomic responses to a combined lifestyle intervention in older adults from the GOTO nonrandomized trial

Fig. 2

The effect of the intervention was studied using two-sided linear mixed model analysis. The significance levels were adjusted for multiple testing using the false discovery rate (FDR). The log2 fold change is plotted on the x axis, the -log10 FDR-adjusted P value is plotted on the y axis. The dashed horizontal line represents the significance threshold of FDR 0.01, the two vertical lines represent the log2 fold change thresholds of −0.25 and 0.25. Genes with an absolute log2 fold change ≥0.25 and an FDR-adjusted P value < 0.01 were considered significantly differentially expressed. Each dot represents a gene. Yellow dots represent the significantly differentially expressed genes (DEGs). Gray dots represent genes with an absolute log2 fold change < 0.25 and/or FDR ≥ 0.01. Significantly differentially expressed genes with the strongest log2 fold changes were labeled with their gene symbol. SAT subcutaneous adipose tissue.

Back to article page