Fig. 6: In postprandial blood, the joint component 1 drivers strongly captured the intervention effect while joint component 2 drivers were significantly associated to whole-body fat% and trunk fat% levels. | Nature Communications

Fig. 6: In postprandial blood, the joint component 1 drivers strongly captured the intervention effect while joint component 2 drivers were significantly associated to whole-body fat% and trunk fat% levels.

From: Secondary integrated analysis of multi-tissue transcriptomic responses to a combined lifestyle intervention in older adults from the GOTO nonrandomized trial

Fig. 6

Associations between the joint component drivers and the intervention effect & metabolic health markers were calculated using a two-sided linear mixed model. The genes were plotted on the y axis, the intervention effect and metabolic health markers were plotted on the x axis. Colors indicate the direction of the effect: blue, a negative effect, white; no effect, red; a positive effect, the darker the color, the stronger the effect. The P values were adjusted using the false discovery rate. Significance is indicated by the asterisks (*FDR <0.05).

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