Table 2 Effect of the 13-week lifestyle intervention on metabolic health marker measurements differs per subset selection

From: Secondary integrated analysis of multi-tissue transcriptomic responses to a combined lifestyle intervention in older adults from the GOTO nonrandomized trial

 

Complete GOTO dataset

153 (75 male, 78 female)

Overlapping blood, SAT and

muscle samples 57 (33 male, 24 female)

Blood postprandial samples 88 (45 male, 43 female)

SAT postprandial samples 78 (38 male, 40 female)

Muscle postprandial samples 82 (48 male, 34 female)

Health marker, mean (SD)

Sex

Delta (SD)

P adjust

Delta (SD)

P adjust

Delta (SD)

P adjust

Delta (SD)

P adjust

Delta (SD)

P adjust

BMI, kg/m2

Male

−1.09 (0.78)

2.4e-18*

−1.02 (0.78)

1.8e-07*

−1.15 (0.79)

1.4e-11*

−1.10 (0.77)

1.3e-09*

−1.18 (0.78)

6.9e-13*

Waist circumference

Male

−4.49 (5.26)

1.8e-09*

−3.82 (4.97)

1.1e-03*

−4.47 (5.29)

1.1e-05*

−4.42 (5.10)

4.8e-05*

−4.94 (5.41)

8.7e-07*

Systolic blood pressure, mm Hg

Male

−3.25 (12.54)

2.8e-01

−3.80 (14.36)

1.0e + 00

−2.52 (13.42)

1.0e + 00

−3.91 (14.14)

9.7e-01

−3.05 (13.53)

1.0e + 00

Diastolic blood pressure, mm Hg

Male

−0.75 (6.98)

1.0e + 00

−3.04 (7.09)

1.9e-01

−2.27 (6.67)

2.7e-01

−3.09 (7.10)

1.1e-01

−2.32 (6.86)

2.3e-01

Fasting insulin, mU/L

Male

−0.31 (3.30)

1.0e + 00

0.14 (3.63)

1.0e + 00

0.04 (3.62)

1.0e + 00

−0.11 (3.71)

1.0e + 00

−0.23 (3.72)

1.0e + 00

Whole-body fat, %

Male

−1.60 (1.65)

1.2e-09*

−1.17 (1.55)

1.5e-03*

−1.43 (1.71)

8.2e-06*

−0.92 (1.52)

9.3e-05*

−1.77 (1.66)

4.8e-07*

Trunk fat, %

Male

−2.47 (2.13)

3.2e-12*

−1.96 (1.81)

3.3e-05*

−2.26 (2.13)

2.3e-07*

−1.48 (1.74)

1.1e-06*

−2.59 (2.04)

8.7e-09*

Fasting HDL cholesterol, mmol/L

Male

0.04 (0.14)

8.2e-02

0.04 (0.13)

1.0e + 00

0.06 (0.14)

7.7e-02

0.05 (0.13)

3.4e-01

0.07 (0.14)

1.7e-02*

Fasting HDL cholesterol size, nm

Male

0.06 (0.09)

2.0e-06*

0.06 (0.08)

9.9e-04*

0.08 (0.08)

2.0e-06*

0.06 (0.09)

4.6e-04*

0.08 (0.09)

1.3e-06*

FRS

Male

−0.40 (1.22)

5.8e-02

−0.61 (1.37)

1.6e-01

−0.53 (1.25)

6.6e-02

−0.58 (1.31)

9.7e-02

−0.54 (1.24)

3.9e-02*

BMI, kg/m2

Female

−1.23 (0.82)

1.4e-20*

−1.26 (0.72)

1.4e-07*

−1.27 (0.64)

2.7e-15*

−1.35 (0.73)

3.0e-13*

−1.36 (0.74)

2.5e-11*

Waist circumference

Female

−4.33 (5.57)

1.4e-08*

−4.71 (5.74)

5.4e-03*

−4.70 (5.30)

7.5e-06*

−4.58 (5.31)

3.0e-05*

−5.21 (5.32)

2.3e-05*

Systolic blood pressure, mm Hg

Female

−3.01 (11.69)

2.6e-01

−1.67 (11.69)

1.0e + 00

−2.85 (11.30)

1.0e + 00

−2.46 (11.73)

1.0e + 00

−1.35 (12.07)

1.0e + 00

Diastolic blood pressure, mm Hg

Female

−1.25 (6.52)

9.5e-01

−1.19 (5.75)

1.0e + 00

−1.66 (5.64)

6.1e-01

−2.29 (6.27)

2.6e-01

−1.43 (6.54)

1.0e + 00

Fasting insulin, mU/L

Female

−0.36 (3.25)

1.0e + 00

−0.30 (2.35)

1.0e + 00

−0.02 (3.01)

1.0e + 00

−0.33 (3.63)

1.0e + 00

−0.90 (2.84)

7.3e-01

Whole-body fat, %

Female

−1.57 (1.70)

9.8e-09*

−1.33 (2.22)

1.1e-02*

−1.64 (1.85)

5.2e-05*

−1.58 (1.98)

7.2e-05*

−1.98 (2.07)

2.5e-04*

Trunk fat, %

Female

−2.22 (2.15)

3.1e-10*

−1.76 (2.78)

7.1e-03*

−2.32 (2.36)

1.2e-05*

−2.31 (2.48)

2.6e-05*

−2.60 (2.57)

1.1e-04*

Fasting HDL cholesterol, mmol/L

Female

−0.04 (0.15)

2.7e-01

−0.03 (0.14)

1.0e + 00

−0.05 (0.16)

4.7e-01

−0.05 (0.15)

5.9e-01

0.00 (0.14)

1.0e + 00

Fasting HDL cholesterol size, nm

Female

0.03 (0.08)

1.7e-02*

0.05 (0.09)

1.7e-01

0.02 (0.08)

6.0e-01

0.04 (0.08)

2.6e-02*

0.04 (0.09)

9.1e-02

FRS

Female

−0.65 (1.60)

5.5e-03*

−0.46 (1.59)

1.0e + 00

−0.42 (1.47)

6.8e-01

−0.62 (1.76)

3.1e-01

−0.68 (1.79)

3.4e-01

  1. SD standard deviation, SAT subcutaneous adipose tissue, BMI body mass index, FRS Framingham Risk Score.
  2. Significance levels were calculated using a two-sided linear mixed model. P values were adjusted for multiple tests using the Bonferroni correction method. An adjusted P value below 0.05 was considered significant. Significant effects are indicated by an asterisk.
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