Fig. 8: Ikaros modulation of IKBKE expression via lupus risk SNP.
From: High-throughput identification of functional regulatory SNPs in systemic lupus erythematosus
The lupus risk SNP rs2297550 allelically modulates the binding of the transcription factor Ikaros (encoded by IKZF1) to regulate the expression of IKBKE, encoding IKKε, a protein that modulates multiple processes implicated in SLE pathogenesis. Note that Ikaros binding can either amplify or repress IKBKE depending on context; amplification, shown here, reflects the direction of effect observed in genotyped healthy donors. The role of mechanisms downstream of IKKε remains to be defined. Figure 8 was created with BioRender.com released under a Creative Commons Attribution-NonCommerical-NoDerivs 4.0 International license.
