Fig. 4: The mRNA-1273 vaccination induced Spike S1-specific IgG concentrations. | Nature Communications

Fig. 4: The mRNA-1273 vaccination induced Spike S1-specific IgG concentrations.

From: Multiple vaccine comparison in the same adults reveals vaccine-specific and age-related humoral response patterns: an open phase IV trial

Fig. 4

A The pre- and 28- days post 2nd mRNA-1273 vaccination Spike S1-specific IgG concentrations (BAU/mL) (presented on a log10 scale) split by age group (young adults n = 43, middle-aged adults n = 75, older adults n = 84). The boxplots indicate the median and interquartile range. All individual values, from min to max, are plotted behind the boxplot (B) The nucleocapsid (N) specific IgG concentrations (BAU/mL) at the pre-vaccination timepoint compared between the different age groups. The dotted line indicated the N-specific cut-off for seropositivity (14.3 BAU/mL). C The longitudinal (pre-, 28 days, and 6 months post 2nd mRNA-1273 vaccination) S1-specific IgG concentrations split by the different age groups (young adults n = 41, middle-aged adults n = 73, and older adults n = 82). The lines indicate the mean and standard error of the mean. No statistics are indicated in this graph. In both (A and C), the gray dotted line (S1-specific IgG = 10 BAU/mL) indicates the cut-off for seropositivity. The black dotted line (S1-specific IgG = 300 BAU/mL) indicates the cut-off for a high response. Source data are provided as a Source data file.

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