Fig. 6: WD34 suppression of P. berghei parasitaemias in BALB/c mice. | Nature Communications

Fig. 6: WD34 suppression of P. berghei parasitaemias in BALB/c mice.

From: A broadly cross-reactive i-body to AMA1 potently inhibits blood and liver stages of Plasmodium parasites

Fig. 6

a Experimental design and WD34 treatment schedule (n = 3 for untreated controls, n = 3 for chloroquine-treated controls, and n = 4 for WD34 treatment). Treatments were given once daily (Q.D). One experiment was performed. b Level of suppression of P. berghei infections by WD34. Data are represented as means ± SEM. Statistical analysis: 1-way ANOVA with multiple comparisons. c In vivo efficacy of WD34 against P. berghei infections using Peters' 4-day suppressive test. d Development of parasitaemias in untreated control mice, chloroquine-treated control mice, and WD34-treated mice. Recrudescences were seen with chloroquine due to giving a single dose on day 0. Data are presented as mean values ± SD. Source data are provided as a Source Data file. e Survival of WD34-treated mice was similar to untreated control mice. f Immunoblot with WD34 of uninfected erythrocytes (Ui) and erythrocytes infected with P. berghei expressing mCherry-luciferase (Pb) under reducing and non-reducing conditions. At least two independent experiments were performed.

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