Fig. 7: Conservation of residues in Plasmodium AMA1 that interact with WD34. | Nature Communications

Fig. 7: Conservation of residues in Plasmodium AMA1 that interact with WD34.

From: A broadly cross-reactive i-body to AMA1 potently inhibits blood and liver stages of Plasmodium parasites

Fig. 7

a Alignment of AMA1 sequences of multiple Plasmodium species showing conservation of WD34 contact residues (<4 Å) identified in the Pf and Pv AMA1-WD34 complexes. Polar interactions are shown in grey boxes and van der Waals bonds are shown in open boxes. b–d Percentage conservation of WD34 contact residues in AMA1 of multiple isolates: b P. falciparum (1054 sequences); c P. vivax (586 sequences); and d Plasmodium species (1745 sequences). Polar interactions are shown in red and van der Waals interactions are shown in blue. A detailed analysis is provided in Supplementary Fig. 12 and Supplementary Data 1.

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