Table 1 A meta-analysis of genetic association studies with PPMS (n = 1104) in comparison to BOMS (n = 11,335)

From: A genetic-epigenetic interplay at 1q21.1 locus underlies CHD1L-mediated vulnerability to primary progressive multiple sclerosis

SNPa

BP

Meta-analysis

SWE (n = 9850)

ITA (n = 2589)

CHR

LD#

A1

P

OR

P

OR

P

OR

rs900347

145726727

1

1

A

0.0285

0.90

0.0352

0.87

0.3624

0.94

rs11800992

146501783

1

2

A

0.0093

0.82

0.0260

0.78

0.1399

0.85

rs72691008

146708291

1

3

A

0.0017

0.69

0.0083

0.69

0.0895

0.70

rs7514808

146570076

1

4

A

0.0286

0.89

0.0367

0.86

0.3632

0.93

rs72706463

146615555

1

5

A

0.0458

1.29

0.1141

1.37

0.2002

1.24

rs10453880

146693689

1

6

T

0.0065

1.26

0.1083

1.21

0.0236

1.32

rs145465008

146630173

1

7

C

0.0293

1.51

0.4867

1.17

0.0048

2.54

rs115153075

146978424

1

8

T

0.0006

1.48

0.0058

1.42

0.0303

1.74

rs12096043

147060953

1

9

T

0.0001

1.84

0.0005

2.03

0.0633

1.58

rs672619

147058575

1

10

T

0.0013

1.34

0.0374

1.32

0.0146

1.35

rs10494248

147108260

1

11

A

0.0079

1.72

0.0270

1.68

0.1386

1.82

rs140566115

147126437

1

12

A

0.0244

1.53

0.0335

1.66

0.3586

1.34

rs116430961

147312516

1

13

C

0.0101

1.62

0.1335

1.44

0.0265

1.93

rs61740912

147313970

1

14

G

0.0012

1.86

0.0098

1.81

0.0483

1.97

rs112044341

147317235

1

15

A

0.0193

1.47

0.0577

1.46

0.1707

1.49

rs74123747

147382534

1

16

T

0.0496

1.27

0.2194

1.20

0.0813

1.50

  1. PPMS primary progressive MS, BOMS bout-onset MS (RRMS + SPMS), OR odds ratio, LD# linkage disequilibrium block, SWE Swedish cohort, ITA Italian cohort, CHR chromosome; P P-value, A1 effect allele, BP base pair (GRCh37/hg19).
  2. aSNP ID highlighted in bold remains significant after Bonferroni correction for multiple testing (p < 7.2 × 10−4).
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