Table 3 Broad-spectrum activity of EDP-235 against human coronaviruses
Virus (Clinical Isolate) | Assay Details | +/− PGPi | IC50 or EC50 [nM] | N |
|---|---|---|---|---|
SARS-CoV | Biochemical1 | − | 5.4 | 3 |
Toronto-2 isolate, Vero E6 / CPE2 | + | 24 | 2 | |
HKU-39849 isolate, Vero E6 / VYR3 | + | < 0.5 | 3 | |
MERS-CoV | Biochemical1 | − | 70 | 3 |
EMC/2012 isolate, Vero E6 / VYR3 | + | 7 | 4 | |
HCoV-229E | Biochemical1 | − | 1.9 | 3 |
MRC-5 / CPE1 | − | 3.6 | 16 | |
MRC-5 / RT-qPCR1 | − | 1.4 | 2 | |
3D pHAEC-ALI / RT-qPCR1 | − | 0.66 | 3 | |
HCoV-OC43 | Biochemical1 | − | 3.4 | 3 |
HCT-8 / RT-qPCR1 | − | 47 | 2 | |
HCoV-HKU1 | Biochemical1 | − | 3.8 | 3 |
HCoV-NL63 | Biochemical1 | − | 1.8 | 3 |
LLC-MK2 / RT-qPCR1 | − | 6.1 | 6 |
