Fig. 1: Genetic region and biosynthesis of the Salmonella T1 antigen. | Nature Communications

Fig. 1: Genetic region and biosynthesis of the Salmonella T1 antigen.

From: Structure, biosynthesis and regulation of the T1 antigen, a phase-variable surface polysaccharide conserved in many Salmonella serovars

Fig. 1

a The T1 antigen biosynthesis cluster in Salmonella enterica serovar Typhimurium SL3770 (LT2) (NC_003197.2). The cluster is a highly conserved ~12,500 base pair region between pxpA and nei in Salmonella. STM0726 (in bold) encodes the Ribf-transferase used to identify the cluster. Genes responsible for galactofuranose addition are colored yellow, and genes responsible for ribofuranose addition are shown in pink. The ABC transporter components are shown in green and the tyrosine recombinase (characterized in Fig. 5) is shown in red. b The biosynthetic pathway for T1 antigen biosynthesis established in this study. c Cartoon representation of the biosynthesis and export steps of the T1 antigen. Note that biosynthesis and export are separated for simplicity, but in the cell these processes are expected to be obligatorily coupled.

Back to article page