Fig. 3: Genetic ablation of sensory neurons abolishes capsaicin-inducing exacerbation of rosacea-like dermatitis. | Nature Communications

Fig. 3: Genetic ablation of sensory neurons abolishes capsaicin-inducing exacerbation of rosacea-like dermatitis.

From: High-sensitive sensory neurons exacerbate rosacea-like dermatitis in mice by activating γδ T cells directly

Fig. 3

A Diagram of the experimental paradigm in (A–E). Capsaicin or vehicle on day -1 before intradermal injection of PBS or LL37 in WT or Nav1.8-DTR mice. B Representative photo and HE staining and (C) The redness score, area of erythema and skin thickness (n = 5 for each group) and (D) The mRNA levels of rosacea-characteristic factors in the skin of vehicle or capsaicin-treated RTX mice after LL37 injection (n = 4–6 for each group). Data represent the mean ± SEM. ns, p > 0.05. Two-way ANOVA with Bonferroni’s post hoc test was used. E The CD4+ T cells infiltration and the CD31+ microvascular in the skin of vehicle or capsaicin-treated RTX mice after LL37 injection.

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