Fig. 9: Rimegepant attenuated nerve-mediated rosacea aggravation. | Nature Communications

Fig. 9: Rimegepant attenuated nerve-mediated rosacea aggravation.

From: High-sensitive sensory neurons exacerbate rosacea-like dermatitis in mice by activating γδ T cells directly

Fig. 9

A Diagram of the experimental paradigm in (A–E). Mice were coadministered capsaicin with rimegepant on day −1 before intradermal injection of PBS or LL37. B Representative photo and HE staining and (C) The redness score, area of erythema and skin thickness of skin tissues in rimegepant and capsaicin-treated mice after LL37 injection (n = 4 for each group). D The mRNA levels of rosacea-characteristic factors (n = 3 or 4 for each group) and (E) CD4+ T cells infiltration (n = 8 for each group) and CD31+ microvasculature (n = 4 for each group) in the skin of rimegepant and capsaicin-treated mice after LL37 injection. Data represent the mean ± SEM. ns, p > 0.05. Two-way ANOVA test was used.

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