Fig. 4: Protein–protein interaction network and enrichment analyses with TWAS risk genes of AD dementia by Avg-valid + SR models. | Nature Communications

Fig. 4: Protein–protein interaction network and enrichment analyses with TWAS risk genes of AD dementia by Avg-valid + SR models.

From: SR-TWAS: leveraging multiple reference panels to improve transcriptome-wide association study power by ensemble machine learning

Fig. 4

A A major network consisting of 23 TWAS risk genes is identified, including the well-known AD risk genes of TOMM40, APOC1, APOC2, and TNF. B Enriched phenotypes include AD-related phenotypes such as family history of AD, lipoprotein measurements, mental or behavioral disorder biomarkers, inflammatory biomarker measurements, and beta-amyloid 1–42 measurements.

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