Table 3 Comparison of CV R² of BRNSNG tissue for valid gene expression imputation models given by training base models with GTEx V8 reference panel of multiple tissues, validation base models, SR-TWAS models, and Avg-valid + SR models

	Sample size	Median CV R²	Mean CV R²	N_genes
TIGAR_GTEx_BRNACC⁹^a	136	0.040	0.062	23068
TIGAR_GTEx_BRNCDT⁹^a	173	0.034	0.063	23362
TIGAR_GTEx_BRNCTXA⁹^a	184	0.033	0.066	23379
TIGAR_GTEx_BRNNCC⁹^a	182	0.033	0.060	23382
TIGAR_GTEx_BRNPTM⁹^a	154	0.037	0.062	22481
TIGAR_GTEx_BLOOD⁹^a	574	0.020	0.071	16682
TIGAR_GTEx_BRNSNG⁹^b	101	0.050	0.068	23051
PrediXcan_GTEx_BRNSNG^7,8,18^b	101	0.052	0.080	2559
SR-TWAS_GTEx_BRNSNG	-	0.068	0.094	22913
Avg-valid + SR	-	-	-	21683

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