Fig. 2: CD45RBlo activated B cells respond to COVID-19 and vaccination but CD45RBhi activated B cells expand during bacterial sepsis. | Nature Communications

Fig. 2: CD45RBlo activated B cells respond to COVID-19 and vaccination but CD45RBhi activated B cells expand during bacterial sepsis.

From: Atypical and non-classical CD45RBlo memory B cells are the majority of circulating SARS-CoV-2 specific B cells following mRNA vaccination or COVID-19

Fig. 2

A Schematic of COVID-19 and Sepsis cohort. B Proportions of B cell clusters in COVID-19 and Sepsis ICU patients across time compared to age-matched healthy controls (n = indicated in 2 A). Other B cell populations shown in Supplementary Fig. 2B. C Schematic of SARS-CoV2 mRNA vaccination cohort. Created with Biorender.com. D Proportions of B cell clusters in SARS-CoV2 mRNA vaccination cohort (n = indicated in C). Significance testing in comparison to with pre-first except when indicated. Multiplicity adjusted p-values from EdgeR (two sided). Single symbols P ≤ 0.05, double P ≤ 0.01, triple P ≤ 0.001. Box plots are median +/- interquartile range (IQR), whiskers are 1.5*IQR. A–C Created with BioRender.com released under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International license (https://creativecommons.org/licenses/by-nc-nd/4.0/deed.en).

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