Fig. 5: Genome-wide FWS distribution by microhaplotype-based complexity of infection (COI). | Nature Communications

Fig. 5: Genome-wide FWS distribution by microhaplotype-based complexity of infection (COI).

From: Lineage-informative microhaplotypes for recurrence classification and spatio-temporal surveillance of Plasmodium vivax malaria parasites

Fig. 5

Data from n = 922 high-quality biologically independent samples from Africa (AF), East Southeast Asia (ESEA), Maritime Southeast Asia (MSEA), Oceania (OCE), South America (SAM), West Asia (WAS) and West Southeast Asia (WSEA). Panel (a) provides boxplots illustrating the distribution of genome wide FWS scores in each of the monoclonal and polyclonal infection subsets as determined by THEREALMcCOIL analysis of the SNPs in the 100 microhaplotypes using the proportional function. Each boxplot presents the median, interquartile range and min and max of the FWS. In all geographic regions, the median genome-wide FWS scores are closer to 1 (little to no within-host diversity) in the infections defined as monoclonal. Panel (b) illustrates the correlation between genome-wide FWS and microhaplotype-based COI estimates; a trend of decreasing COI is observed with increasing FWS (i.e., decreasing within-host diversity).

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