Table 1 Summary statistical analysis of the most reactive gonococcal antigens against IgG following vaccination with 4CMenB

From: Profiling IgG and IgA antibody responses during vaccination and infection in a high-risk gonorrhoea population

Label

Function

% identitya

NEIS69

4CMenB Recombinant?b

Staged

p valuec

NHBA

Heparin-binding protein

68e

NEIS2109

x

t0:t10

6.47E-13

GNA2091

Hemolysin/lipoprotein

96e

NEIS2071

x

t0:t10

6.47E-13

BamE

Outer membrane protein assembly

93

NEIS0196

 

t0:t10

6.37E-09

lipoprotein 1

Genome-derived Neisseria antigen 1162

97

NEIS1063

 

t0:t10

2.54E-08

Factor H binding protein

Binds to serum Factor H

63e

NEIS0349

x

t0:t10

2.57E-06

PIII/RmpM

PorB stabilisation

93

NEIS1783

 

t0:t10

3.94E-06

NGO1225

Peptidyl-prolyl isomerase

98

NEIS1487

 

t0:t10

3.12E-04

GNA1030

Lipid/polyisoprenoid-binding; YceI-like

93e

NEIS1183

x

t0:t10

9.56E-04

LolB

Lipoprotein localisation

96

NEIS0814

 

t0:t10

2.05E-03

NGO0432

Porin-like protein

98

NEIS0807S

 

t0:t10

7.85E-03

NHBA

Heparin-binding protein

68e

NEIS2109

x

t0:t24

6.54E-13

GNA2091

Hemolysin/lipoprotein

96e

NEIS2071

x

t0:t24

1.94E-12

PIII/RmpM

PorB stabilisation

93

NEIS1783

 

t0:t24

5.19E-08

Factor H binding protein

Binds to serum Factor H

63e

NEIS0349

x

t0:t24

3.13E-06

IgA protease

IgA cleavage/immune evasion

88

NEIS0651

 

t0:t24

1.05E-05

NGO1847

Transmembrane protein with TPR repeat

-f

NEIS2724

 

t0:t24

1.32E-04

GNA1030

Lipid/polyisoprenoid-binding; YceI-like

93e

NEIS1183

x

t0:t24

2.73E-04

PilC

Type IV pilus-related function

73

NEIS0371

 

t0:t24

4.40E-04

membrane protein 2

Membrane-associated lipoprotein

97

NEIS1304

 

t0:t24

4.89E-04

Transferrin binding B

Iron uptake

61

NEIS1691

 

t0:t24

5.19E-04

BamA

Outer membrane protein assembly

88

NEIS0173

 

t0:t24

6.40E-04

lipoprotein 2

BamC; outer membrane protein assembly

97

NEIS0906

 

t0:t24

6.78E-04

NGO2086

Surface-exposed, possible adhesin

-f

NEIS2733

 

t0:t24

7.10E-04

NGO1040

Porin-like protein

92

NEIS1404

 

t0:t24

7.10E-04

PhospholipasePhospholipase

Hydrolysis of phosphatidylcholine

99

NEIS1687

 

t0:t24

1.03E-03

LolB

Lipoprotein localisation

96

NEIS0814

 

t0:t24

1.74E-03

LbpB

Iron uptake

74

NEIS1469

 

t0:t24

2.36E-03

Maf1/MafA

Adhesin

98

NEIS2083

 

t0:t24

2.58E-03

NGO1430

TonB-coupled transporter

-f

NEIS2697

 

t0:t24

2.72E-03

BamE

Outer membrane protein assembly

93

NEIS0196

 

t0:t24

2.82E-03

PilE

Type IV pilin protein

66

NEIS0210

 

t0:t24

3.36E-03

LptD

LPS assembly protein

90

NEIS0275

 

t0:t24

3.53E-03

PilQ

Secretin; Type IV pilus assembly

91

NEIS0408

 

t0:t24

4.19E-03

PorB_537_89

Porin protein

66

NEIS2020 allele 537

 

t0:t24

7.23E-03

TamB

Translocation/assembly

97

NEIS2113

 

t0:t24

8.64E-03

  1. a% identity between FA1090 protein as immobilised on the array slide (with the His tag removed) and the equivalent protein in the NZ98/254 strain used in 4CMenB or closest equivalent in another strain.
  2. bDenotes recombinant proteins in the 4CMenB formulation.
  3. cCalculated using a one-sided Wilcoxon paired rank test with correction after Hommel67, listed in increasing order of p value. Only antigens with p < 0.01 are listed.
  4. dPaired t0 with t10 or t0 with t24.
  5. eAs reported by ref. 16.
  6. fNo close homologues in Neisseria meningitidis.
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