Fig. 6: In vivo biodistribution and pharmacokinetic of BSA-multiblock polymer conjugates in BALB/c mice. | Nature Communications

Fig. 6: In vivo biodistribution and pharmacokinetic of BSA-multiblock polymer conjugates in BALB/c mice.

From: Sequence-encoded bioactive protein-multiblock polymer conjugates via quantitative one-pot iterative living polymerization

Fig. 6

a In vivo fluorescence images of BALB/c mice at different time intervals after intravenous injection of Cy5.5, Cy5.5-labeled BSA, and Cy5.5-labeled BSA-multiblock polymer conjugates, respectively. b Quantitation analysis of fluorescence intensity in major organs after injection of Cy5.5-labeled BSA and Cy5.5-labeled BSA-multiblock polymer conjugates for 1 h, 4 h, and 8 h. The data are shown as mean ± SD (n = 3). Statistical significance was assessed using a one-way ANOVA with Fisher’s LSD test (*p < 0.05, **p < 0.01, and ***p < 0.001). The exact p values are provided in Source Data file. c Ex vivo images of excised tissues after injection of Cy5.5-labeled BSA and Cy5.5-labeled BSA-multiblock polymer conjugates. d Plasma concentrations of BSA and BSA-multiblock polymer conjugates versus time. The data are shown as mean ± SD (n = 3) for b and d. Source data are provided as a Source Data file.

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