Fig. 6: Comparison of KAP/CKS1/CDC25A with GDSEID binding region of CDK2. | Nature Communications

Fig. 6: Comparison of KAP/CKS1/CDC25A with GDSEID binding region of CDK2.

From: Cryo-EM structure of the CDK2-cyclin A-CDC25A complex

Fig. 6

a Overlay of the trimeric complex (CDK2-Cyclin A in grey, CDC25A in green) with the CDK2-KAP crystal structure (PDB 1FQ1, KAP in blue) and (c) CDK2-CKS1 crystal structure (PDB 1BUH, CKS1 in orange). The CDK2 GDSEID sequence and αG helix are highlighted in yellow. b Ribbon diagram of the GDSEID region of CDK2 bound to CDC25A (green) and KAP (blue), which bind to opposing faces of the αG helix. d Ribbon diagram of the GDSEID region of CDK2 bound to CDC25A (green) and CKS1 (orange), showing an overlap in the binding region but differences in specific residue interactions.

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